Creatine: rapid energy supply, increase lean body mass - multi-nutrient, joint resistance to sarcopenia

2022-09-27

Creatine, also known as N-methylguanidine acetic acid, is a naturally occurring nitrogenous organic acid, which can also be synthesized from arginine, glycine and methionine and other three amino acids in the body. In the human body, about 3% of creatine is found in skeletal muscle, and the remaining small amounts of creatine are also found in the brain and testicles. There are 95 forms of creatine in the human body, 2/2 is phosphocreatine, and the remaining 3/1 is free creatine.

01. Physiological functions of creatine

The physiological effects of creatine are mainly as follows:

(1) The role of energy substances. The energy of skeletal muscle comes from the decomposition of adenosine triphosphate (ATP), and creatine can be converted to creatine phosphate to synthesize ATP, so the increased concentration of creatine in the muscle can provide rapid energy supply substances and increase muscle strength.

(2) Increase lean body mass. Creatine can increase the rate of muscle protein synthesis, thereby increasing lean body mass.

(3) The role in muscle acid-base balance. The human body produces lactic acid during short-term high-intensity exercise, and the accumulation of lactic acid will cause the pH value in the muscles to drop and produce muscle fatigue. When the buffer in muscle cells cannot resist the change of pH, phosphocreatine in muscle will be decomposed under the catalysis of creatine kinase to generate ATP and creatine, which neutralizes the pH value, thereby reducing the damage of harmful substances to the human body, achieving anti-fatigue and promoting recovery.